## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
Reversal of Effects of 2-Substituted Thiadiazoles by Nicotinamide Analogues and Precursors
β Scribed by KRAKOFF, IRWIN H.; LACON, CORRINE R.; KARNOFSKY, DAVID A.
- Book ID
- 109604033
- Publisher
- Nature Publishing Group
- Year
- 1959
- Tongue
- English
- Weight
- 223 KB
- Volume
- 184
- Category
- Article
- ISSN
- 0028-0836
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## Abstract The condensation reaction of thiobenzamide, (as well as thionicotinamide and isothionicotinamide) in the presence of dimethyl sulfoxide and of an acid, affords 3,5βdiphenylβ1,2,4βthiadiazole. Under the same experimental conditions, __N__βsubstituted thioureas are also condensed to 1,2,4
Under the influence of hydrogen peroxide and hydrochloric acid in acetonitrile 4-substituted benzo-2,1,3-thiadiazoles form 5-chloro-4,7-dioxobenzo-2,1,3thiadiazole. 4-Alkoxy-and 4-[(alkoxycarbonyl)methoxy]benzo-2,1,3-thiadiazoles give, in addition, the corresponding 5,7-dichloro derivatives. 5-Chlo