Reversal of atrial natriuretic peptide resistance by increasing distal tubular sodium delivery in patients with decompensated cirrhosis*1, *2

Reversal of atrial natriuretic peptide r

Reversal of atrial natriuretic peptide resistance by increasing distal tubular sodium delivery in patients with decompensated cirrhosis

✍ William T. Abraham; Marije E. Lauwaars; Jin K. Kim; Ricardo L. Peñna; Robert W. 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 783 KB

To test the hypothesis that diminished sodium delivery to the distal tubular site of atrial natriuretic peptide (A") action accounts for renal ANP resistance in cirrhosis, 12 cirrhotic patients with ascites were studied at baseline and during the infusion of ANP alone (0.15 pg/ kg/min), mannitol alo