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Reversal effect of tyroservatide (YSV) tripeptide on multi-drug resistance in resistant human hepatocellular carcinoma cell line BEL-7402/5-FU

✍ Scribed by Lin-xi Shi; Rui Ma; Rong Lu; Qiong Xu; Zhi-feng Zhu; Li Wang; Chun-lei Zhou; Xiao-lei Li; Hua-li Zhang; Zhi Yao

Book ID: 116334816
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 487 KB
Volume: 269
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2008.04.033

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## Abstract In this study, oroxylin A showed strong reversal potency in BEL7402/5‐FU cells and the reversal fold (RF) reached 4.69. Simultaneously, rhodamine‐123 accumulation assay and flow cytometry analysis demonstrated oroxylin A could increase drug accumulation. When combined with oroxylin A, 5