Rett Syndrome and the Impact of MeCP2 Associated Transcriptional Mechanisms on Neurotransmission
β Scribed by Lisa M. Monteggia; Ege T. Kavalali
- Book ID
- 119198084
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 582 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0006-3223
No coin nor oath required. For personal study only.
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Methylated CpG Binding Protein 2 (MeCP2) is a nuclear protein named for its ability to selectively recognize methylated DNA. Much attention has been focused on understanding MeCP2 structure and function in the context of its role in Rett syndrome, a severe neurodevelopmental disorder that afflicts o
The study of transcription using genomic tiling arrays has lead to the identification of numerous additional exons. One example is the MECP2 gene on the X chromosome; using 5'RACE and RT-PCR in human tissues and cell lines, we have found more than 70 novel exons (RACEfrags) connecting to at least on