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Retrovirus-mediated gene transfer to myocytes. An approach to muscle gene therapy

✍ Scribed by SALMINEN, A; ELSON, H; MICKLEY, L; FOJO, A; GOTTESMAN, M


Book ID
122126579
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
131 KB
Volume
14
Category
Article
ISSN
0309-1651

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Transfer of therapeutic genes into muscle tissue has promise for the treatment of a variety of muscular dystrophies. Various vectors have been used to deliver genes to skeletal muscle but their application has faced several major limitations including: (1) the lack of transgene persistence caused by