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Retroviral transfer of interleukin-1α and interleukin-6 genes into mouse hematopoietic stem cells

✍ Scribed by Pengas, Ioannis; Assiotis, Angelos; Nash, William; Hatcher, Julian; Banks, Joanne; Mcnicholas, Michael J.


Book ID
122028853
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
152 KB
Volume
1
Category
Article
ISSN
1043-4666

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## Abstract Low O~2~ concentration (1%) favors the self‐renewal of hematopoietic stem cells and inhibits committed progenitors (CFC). Since IL‐6 influences both stem cells and committed progenitors at 20% O~2~, we studied its effects in cultures at 1% O~2~. The pre‐CFC activity in Lin− population o