## Abstract The integration of viral cDNA into the host genome is an essential step in the HIVβ1βlife cycle and is mediated by the virally encoded enzyme, integrase (IN). Inhibition of this process provides an attractive strategy for antiviral drug design. The discovery of Ξ²βdiketo acid inhibitors
Retroviral integrase inhibitors year 2000: update and perspectives
β Scribed by Yves Pommier; Christophe Marchand; Nouri Neamati
- Book ID
- 114144105
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 134 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0166-3542
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## Abstract HIVβ1 integrase (IN) catalyzes the integration of proviral DNA into the host genome, an essential step for viral replication. Inhibition of IN catalytic activity provides an attractive strategy for antiretroviral drug design. Currently two IN inhibitors, MKβ0518 and GSβ9137, are in adva
In recent years, HIV-1 integrase (IN) has become an attractive target for designing antiretroviral agents. The first IN inhibitor approved for clinical use, raltegravir, has validated the pharmacological viability of IN inhibitors and signals the advent of a new generation of antiretroviral drugs. T
## Abstract Review: 139 refs.