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Retroviral gene transfer to chickens for the production of pharmaceutical proteins into eggs

✍ Scribed by Ken-ichi Nishijima; Makoto Motono; Daisuke Kodama; Yoshinori Kawabe; Masamichi Kamihira; Shinji Iijima


Book ID
113682857
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
63 KB
Volume
108
Category
Article
ISSN
1389-1723

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## Abstract ## Background Host immune responses to foreign gene products have been shown to lead to the elimination of genetically modified cells, and are a major barrier to successful therapeutic gene therapy. We have shown that immunological tolerance to retrovirally transduced cell surface prot