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Retroviral gene transfer of an antisense construct against membrane type 1 matrix metalloproteinase reduces the invasiveness of rheumatoid arthritis synovial fibroblasts

✍ Scribed by Edita Rutkauskaite; Dagmar Volkmer; Yukio Shigeyama; Jörg Schedel; Geza Pap; Ulf Müller-Ladner; Ingmar Meinecke; Dorothea Alexander; Renate E. Gay; Susanne Drynda; Wolfram Neumann; Beat A. Michel; Wilhelm K. Aicher; Steffen Gay; Thomas Pap

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 120 KB
Volume: 52
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.21156

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Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblasts

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## Abstract ## Objective To investigate whether retroviral gene transfer of ribozymes targeting matrix metalloproteinase 1 (MMP‐1) inhibits the production of MMP‐1 in rheumatoid arthritis synovial fibroblasts (RASFs) and reduces the invasiveness of these cells in vivo. ## Methods MMP‐1–specific