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Retroviral expression of a FKHR mutant enhances metastasis and apoptosis in a mouse mammary carcinoma model

✍ Scribed by Vafa Ghaemmaghami; Clifford Tepper; Noelle Niemand; Jeff Gregg; Luria Namba


Book ID
113676099
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
53 KB
Volume
199
Category
Article
ISSN
1072-7515

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## Abstract In human breast cancer, mutations in the __p53__ gene are associated with poor prognosis. However, analysis of patient data so far did not clarify, whether missense point mutations in the __p53__ gene, in addition to causing loss of wild‐type p53 function, also confer a gain of function