✦ LIBER ✦

Retrospective estimation of the birth prevalence for delayed onset disorders: application to cystic fibrosis in Nova Scotia

✍ Scribed by Mei Yin Chong; David C. Hamilton; David E. C. Cole

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 93 KB
Volume: 19
Category: Article
ISSN: 0277-6715
DOI: 10.1002/(sici)1097-0258(20000315)19:5<743::aid-sim338>3.0.co;2-f

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✦ Synopsis

Maximum likelihood methods are used to estimate the birth prevalence, the age-at-diagnosis distribution, and the number of infants born with CF in Nova Scotia over a 20 year period. The data were taken from a registry of CF cases, and, because of the delayed onset of symptoms, some CF affected individuals were not diagnosed by the end of the study period. A goodness-of-fit test for assessing whether the age-at-diagnosis distribution is stable over the 20 years is provided. These methods could be applied equally well to data on any genetic disorder with delayed onset.