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Retrograde reactions of Clarke's nucleus neurons after human spinal cord injury

✍ Scribed by Andreas B. Schmitt; Sebastian Breuer; Leyla Polat; Katrin Pech; Byran Kakulas; Seth Love; Didier Martin; Jean Schoenen; Johannes Noth; Gary A. Brook

Book ID
102705104
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
546 KB
Volume
54
Category
Article
ISSN
0364-5134

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Spinal cord injury in adult mammals causes atrophy or death of some axotomized neurons. The product of the antiapoptotic gene Bcl-2 prevents neuron death in vivo. We delivered Bcl-2 by intraspinal injection of a DNA plasmid encoding this gene to determine if axotomized neurons destined to undergo re