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Retrograde axonal transport of neurotrophic factors in vivo: Saltatory transport and lack of involvement of multivesicular bodies

✍ Scribed by A.L. Altick; L.M. Baryshnikova; H. Damke; C.S. von Bartheld


Book ID
116551954
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
587 KB
Volume
26
Category
Article
ISSN
0736-5748

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## Abstract Neurons with long axons have a unique problem in generating signaling cascades that are able to reach the nucleus after receptor activation by neurotrophins at the nerve terminal. The straightforward concept of receptor binding and local generation of 2^nd^ second messenger cascades is