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Retro-Mannich Reactions of 3-Alkyl-3,4-dihydro-2H-1,3-benz[e]oxazines and the Synthesis of Axially Chiral Resorcinarenes.

✍ Scribed by Philip C. Bulman Page; Harry Heaney; Matthew J. McGrath; Edward P. Sampler; Robert F. Wilkins


Publisher
John Wiley and Sons
Year
2003
Weight
80 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract magnified image Reaction of 2‐(5‐substituted‐2‐hydroxybenzylamino)phenols (**2**) with formalin in ethanol under reflux has chemoselectively led to 2‐(6‐substituted‐2__H__β€”benzo[__e__][1,3]oxazin‐3(4__H__)‐yl)phenols (**3**) in good yield involving the ring closure of the hydroxyl grou