## Abstract ## BACKGROUND Pemetrexedβcisplatin chemotherapy is the standard of care in the firstβline treatment of unresectable malignant pleural mesothelioma (MPM). Secondβline cytotoxic therapy is considered for a growing group of patients, but the optimal treatment has not been defined to date.
Retreatment of recurrent malignant pleural mesothelioma with cisplatin and pemetrexed
β Scribed by Hidetoshi Hayashi; Isamu Okamoto; Yasuko Ichikawa; Masaki Miyazaki; Hiroshige Yoshioka; Kei Kunimasa; Kazuhiko Nakagawa
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 296 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1341-9625
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Pleural malignant mesothelioma (MM) is an aggressive cancer with a very long latency and a very short median survival. Little is known about the genetic events that trigger MM and their relation to poor outcome. The goal of our study was to characterize major genomic gains and losses as
mainly located within the cell processes but not within perikarya. The findings thus mimicked those of classic, pediatric neuroblastoma~.~ In contrast, dense core or neurosecretory-type granules in SITA resemble those of enterochromaffin (endocrine) cells of the digestive tract. They are aggregated
## BACKGROUND. Gemcitabine has shown activity in patients with less chemosensitive solid tumors. Phase II screening of novel drugs is an accepted method with which to investigate new therapies in malignant mesothelioma. The European Organization for Research and Treatment of Cancer-Lung Cancer Coo