Retinol conversion to retinoic acid is impaired in breast cancer cell lines relative to normal cells

Increased gap junctional intercellular c

Increased gap junctional intercellular communication is directly related to the anti-tumor effect of all-trans-retinoic acid plus tamoxifen in a human mammary cancer cell line

✍ Claudia G. Sáez; L. Velásquez; M. Montoya; E. Eugenín; M.G. Alvarez 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 363 KB 👁 1 views

## Abstract Additive effects against tumor cells might be achieved by combining anti‐neoplastic agents directed against one or more altered mechanisms in cancer. We investigated the participation of gap junctional intercellular communication (GJIC), which is commonly dysfunctional in tumor cells as