Retinoids inhibit the mitogenic activity of tumourpromoting phorbol esters on human lymphocytes
✍ Scribed by Jochen Abb; Friedrich Deinhardt
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- French
- Weight
- 383 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
The tumour‐promoting agents 12‐0‐tetradecanoyl‐phorbol‐13‐acetate (TPA) and phorbol‐12,13‐dibutyrate (PDB)^1^ are potent mitogens for human peripheral blood lymphocytes. In contrast, the non‐cocarcinogenic substance phorbol lacks lymphocyte‐activating properties. Non‐toxic levels of retinoic acid (RA) or retinyl acetate (RAt) inhibit the phorbol‐ester‐induced lymphocyte proliferation. Selective inhibition of phorbol‐ester‐stimulated lymphocyte blastogenesis required the near‐concurrent addition of retinoids. Differences in the sensitivity of phorbol‐ester‐stimulated lymphocyte subpopulations to the antagonistic action of RA or RAt, respectively, suggest that the inhibitory effect of retinoids may not be due to a common mode of action. Lymphocyte cultures may provide a useful model system for studies of the mechanisms of action of both phorbol esters and retinoids.