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Retinoids exacerbate rat liver fibrosis by inducing the activation of latent TGF-beta in liver stellate cells

✍ Scribed by M Okuno; H Moriwaki; S Imai; Y Muto; N Kawada; Y Suzuki; S Kojima

Book ID
118686697
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
746 KB
Volume
26
Category
Article
ISSN
0270-9139

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## Abstract ## Background/aims Transforming growth factor Ξ² (TGFΞ²1) is considered the key mediator in the process of liver fibrosis. The purpose of this investigation was to evaluate the activity of ribozymes against TGFΞ²1 in a cell‐free system and activated hepatic stellate cells (HSCs), and anti