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Retinoic Acid-Mediated G1 Arrest Is Associated with Induction of p27Kip1 and Inhibition of Cyclin-Dependent Kinase 3 in Human Lung Squamous Carcinoma CH27 Cells

โœ Scribed by Shih-Lan Hsu; Jen-Wen Hsu; Mei-Chun Liu; Ling-Yun Chen; Chi-Der Chang


Book ID
115603730
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
200 KB
Volume
258
Category
Article
ISSN
0014-4827

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Human lung cancer cells, including small cell lung carcinoma (SCLC), frequently lose expression of retinoic acid receptor โค (RAR-โค) and are resistant to the growth inhibitory activity of all-trans retinoic acid (RA). To elucidate the role of RAR-โค in the growth regulation of SCLC by retinoids, we re