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Retinoic acid and the differentiation of lymphohaemopoietic stem cells

✍ Scribed by Bertholdm Göttgens; Anthony R. Green

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
345 KB
Volume
17
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

The study of haemopoiesis enables us to address one of the central questions of developmental biology, concerning the molecular mechanisms by which a multipotent cell develops into distinct differentiated progeny. Recent work(') suggests specific roles for retinoic acid receptors at two distinct stages of haemopoiesis. Continuous cell lines of lymphohaemopoietic progenitors were established by infection with a retrovirus containing a dominant negative retinoic acid receptor. The cell lines depend on stem cell factor for their proliferation and can be induced to diffentiate into Blymphocytes, erythrocytes, neutrophils, monocytes, mast cells and megakaryocytes. Since lymphohaemopoietic progenitors represent less than 0.01 % of nucleated marrow cells, immortalised progenitors provide a valuable system with which to study haemopoiesis on a molecular level.

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