Retinoic acid has been associated with a variety of cardiac defects. A percentage of these defects are related to changes in the endocardial cushions. Studies in mice and older chick embryos have shown a decrease in mesenchymal cell formation attributable to retinoic acid and have suggested that ret
โฆ LIBER โฆ
Retinoic acid administration is associated with changes in the extracellular matrix and cardiac mesenchyme within the endocardial cushion
โ Scribed by Yan, Min ;Sinning, Allan R.
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 119 KB
- Volume
- 263
- Category
- Article
- ISSN
- 0003-276X
- DOI
- 10.1002/ar.1076
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Secreted protein, acidic and rich in cysteine (SPARC), is a multifunctional matricellular glycoprotein. In vitro, SPARC has antiangiogenic properties, including the ability to inhibit the proliferation and migration of endothelial cells stimulated by bFGF and VEGF. Previously, we demonstrated that p