Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf

Acetylation of histones associated with

Acetylation of histones associated with the p21WAF1/CIP1 gene by butyrate is not sufficient for p21WAF1/CIP1 gene transcription in human colorectal adenocarcinoma cells

✍ Hanako Kobayashi; Er Mei Tan; Sharon E. Fleming 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 331 KB

## Abstract Butyric acid is well recognized as a histone deacetylase (HDAC) inhibitor, and changes in histone acetylation are thought to alter gene expression. The mechanism by which sodium butyrate (NaB) induces p21^WAF1/CIP1^, a critical gene involved in the antiproliferative effect of NaB, was s