Retinoblastoma – genetic insights into neoplasia

✍ Scribed by William L. Nyhan

• Book ID: 102759343
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 514 KB
• Volume: 6
• Category: Article
• ISSN: 0265-9247
• DOI: 10.1002/bies.950060103

✦ Synopsis

Retinoblastoma is a highly malignant ocular tumor that has been known to be hereditary in some instances. New information from cytogenetic and molecular studies indicates that there is a retinoblastoma gene and that the mutant alleles are recessive. The wild-type gene appears

to be a suppressor of this neoplasia, and, when both alleles are lost, malignancy develops.