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Retinoblastoma cell cycling

✍ Scribed by Shawnya Kaleta-Michaels; Devron H. Char; Stewart M. Kroll; Frederic M. Waldman

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 435 KB
Volume: 12
Category: Article
ISSN: 0196-4763
DOI: 10.1002/cyto.990120215

No coin nor oath required. For personal study only.

✦ Synopsis

Techniques for the measurement of bromodeoxyuridine (BrdUrd) positive cells generally include either microscopic evaluation of paraffin embedded sections or measurements on cell suspensions using a fluorescent activated cell sorter. The accuracy of these measurements and their correlations can be affected by a number of technical and intrinsic tumor factors. Extrinsic parameters including degree of necrosis and tumor growth fraction are less easily analyzed in BrdUrd stained material.

Retinoblastoma tumor cell cycling was prospectively studied in 11 children using in vivo and one child using in vitro BrdUrd. BrdUrd measurements were made by staining cell suspensions or sections of paraffin embedded tumor and analyzing by microscopy. Approximately

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