Retinitis preceding systemic lupus erythematosus in absence of anti-phospholipid antibodies
โ Scribed by Mario RODENAS; Santhosh KUMAR; Kenneth Bailey FREUND; Jack MOALLEM
- Book ID
- 114930848
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2011
- Tongue
- English
- Weight
- 102 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1756-1841
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๐ SIMILAR VOLUMES
Sera from patients with SLE frequently contain IgM and IgG antibodies with multiple specificities for lymphocyte surface determinants, including autologous antigens. The IgM antibodies are of relatively low binding avidity and exhibit broad reactivity with B and T lymphocytes from most individuals.
Antibody a c t i v i t y t o various histones was examined i n a s o l i d phase radioimmunoassay. More than one h a l f o f the sera from systemic lupus erythematosus (SLE) p a t i e n t s had IgM a c t i v i t y t o t o t a l histones, and a s l i g h t l y lower frequency was observed f o r IgG a