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Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling

✍ Scribed by Lenkowski, Jenny R.; Qin, Zhao; Sifuentes, Christopher J.; Thummel, Ryan; Soto, Celina M.; Moens, Cecilia B.; Raymond, Pamela A.


Book ID
125447479
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
988 KB
Volume
61
Category
Article
ISSN
0894-1491

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TGFbeta inducible early gene (TIEG) is a novel Krüppel-like transcriptional repressor that was recently shown to increase the activity of the TGFbeta/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for