Retinal reductase activity in rats with and without inherited retinal dystrophy
β Scribed by P.A.A. Jansen; F.J.M. Daemen
- Book ID
- 117100546
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 187 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0014-4835
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The inability of retinal pigment epithelium to phagocytose shed photoreceptor disks is a cause of retinal degeneration in the Royal College of Surgeons rat; retinal pigment epithelial phagocytosis and disk shedding are regulated by the diurnal rhythm of retinal melatonin level. The diurnal rhythms o
The primary cause of the inherited retinal dystrophy observed in Royal College of Surgeons (RCS) rats is located in the retinal pigmented epithelium, which is unable to phagocytize photoreceptor outer segments. We have demonstrated here that retinal Mu Β¨ller glial (RMG) cells obtained from RCS dystr