Retinal pigment epithelial cell support of photoreceptor survival in vitro
β Scribed by Harold J. Sheedlo; Wei Fan; Linxi Li; James E. Turner
- Book ID
- 112803578
- Publisher
- Society for In Vitro Biology
- Year
- 1995
- Tongue
- English
- Weight
- 534 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1475-2689
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Phagocytosis of tips of rod outer segments (ROS) by retinal pigment epithelial (RPE) cells is vitally important for maintaining structural and functional integrity of the retina. We previously reported that receptor-mediated specific phagocytosis of ROS induces expression of early response genes cod
## Abstract Retina differentiation involves the acquisition of a precise layered arrangement, with RPE cells in the first layer in intimate contact with photoreceptors in the second layer. Here, we developed an in vitro coculture model, to test the hypothesis that RPE cells play a pivotal role in o