Reticuloendothelial failure in chronic intra-abdominal sepsis: The role of opsonic fibronectin
✍ Scribed by Miss S. Cheslyn-Curtis; M. C. Aldridge; H. A. F. Dudley
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 404 KB
- Volume
- 76
- Category
- Article
- ISSN
- 0007-1323
No coin nor oath required. For personal study only.
✦ Synopsis
chronic i nt ra -a bdominal sepsis: the role of opsonic fibronectin
Severe sepsis leads to depression of the reticuloendothelial ( R E ) system with delayed bloodstream clearance of particulate matter and bacteria. Fibronectin may be an important opsonin of the R E system and low fibronectin levels often accompany severe sepsis in man. W e have investigated the effect of prolonged intra-abdominal sepsis on plasma fibronectin concentrations and R E function. Serial plasma fibronectin concentrations were determined in rabbits for 2 weeks after either the induction of sepsis (appendix abscess) (n = 6 ) or laparotomy only (n=6).
RE function was measured at 2 weeks by determining the clearance kinetics and organ distribution of low dose technetium tin colloid ( T T C ) . There was an early transient depression in plasma fibronectin values followed by elevated concentrations at 48-72 h which
were more marked in the sepsis group. There was a delay in the blood clearance with reduced hepatic and increased bone uptake of T T C . We conclude that depletion of opsonic fibronectin is unlikely to be an important factor contributing to the impairment of RE function associated with intra-abdominal sepsis and that R E depression in septic animals is due to intrinsic Kupffer cell dysfunction.