A number of transgenic animal model systems have addressed the mechanistic role of p53 loss in tumor progression. However, many of these tumor models have analyzed p53 function in the context of other transgenes expressing activated oncogenes or defective tumor suppressor genes generated by gene tar
β¦ LIBER β¦
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation
β Scribed by Venkatachalam, S.
- Book ID
- 111745581
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 421 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0261-4189
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## Abstract ## Background. In the majority of human cancers, the tumor suppressor activity of p53 is impaired because of mutational events or interactions with other proteins (ie, MDM2). The loss of p53 function is responsible for increased aggressiveness of cancers, while tumor chemoresistance an
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