Retention of barbituric acid derivatives on immobilized artificial membrane stationary phase and its correlation with biological activity

Estimation of phospholipophilicity of 1-

Estimation of phospholipophilicity of 1-[3-(arylpiperazin-1-yl)-propyl]-pyrrolidin-2-one derivatives on immobilized artificial membrane stationary phase and its correlation with biological data

✍ Katarzyna Kulig; Barbara Malawska 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 203 KB

A molecule library containing 42 1-[3-(arylpiperazin-1-yl)-propyl]-pyrrolidin-2-one derivatives has been designed and synthesized. The phospholipophilicity of the obtained compounds has been determined using immobilized artificial membrane high-performance liquid chromatography (IAM-HPLC). The perfo