𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Retention characteristics of several compound classes in reversed-phase liquid chromatography with β-cyclodextrin as a mobile phase modifier

✍ Scribed by Reza M. Mohseni; Robert J. Hurtubise

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
1014 KB
Volume
499
Category
Article
ISSN
1873-3778

No coin nor oath required. For personal study only.

✦ Synopsis

&Cyclodextrin was investigated as a mobile phase modifier in the reversedphase liquid chromatography of polycyclic aromatic hydrocarbons, nitrogen heterocycles and hydroxyl aromatics. A wide range of p-cyclodextrin concentrations was employed, and the retention properties of the compound classes were compared in methanol-water and ethanol-water mobile phases at 25°C. p-Cyclodextrin-solute dissociation constants were obtained for the compounds in several methanol-water and ethanol-water mobile phase compositions, using the chromatographic data. The trends in the retention data and dissociation constants for the compound classes were discussed. Several conclusions were drawn concerning the mechanism of retention when /3-cyclodextrin is present in the mobile phases. Also, comparisons were made between the structural features of the compounds and their capacity factors and dissociation constants.

📜 SIMILAR VOLUMES

α-Cyclodextrin as a restricted access mo
α-Cyclodextrin as a restricted access mobile phase for reversed-phase liquid chromatography with fluorimetric detection of phenolic compounds
✍ F.García Sánchez; A.Navas Díaz; J Lovillo; L.S Feria 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 529 KB

A reversed-phase liquid chromatographic (LC) method to determine the phenolic derivatives, p-hydroxybenzoic (PHB), ferulic and vanillic acids, and methyl paraben (MPB), was developed. The mobile phase used was 1 x lo-'M cY-cyclodextrin/ acetate buffer pH 4.6 (l:l), that forms inclusion complexes wit

Enantiomeric separation of acidic compou
Enantiomeric separation of acidic compounds by nano-liquid chromatography with methylated-β-cyclodextrin as a mobile phase additive
✍ Anna Rocco; Salvatore Fanali 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 692 KB

## Abstract Some racemic nonsteroidal anti‐inflammatory drugs, namely naproxen, indoprofen, ketoprofen, flurbiprofen, carprofen, cicloprofen, flunoxaprofen and suprofen were separated into their enantiomers by nano‐LC. Chiral recognition was achieved adding to the mobile phase heptakis (2,3,6‐tri‐_

Retention behaviour of metal chelates in
Retention behaviour of metal chelates in ion-pair reversed-phase liquid chromatography as a function of mobile phase composition with methanol-water and acetonitrile-water mobile phases
✍ Chizuko Ohtsuka; Kimiyo Matsuzuwa; Hiroko Wada; Genkichi Nakagawa 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 517 KB

The retention behaviour of Cu(II), Co(III), Nit111 and Fe(H) chelates with 2-(5-bromo-2-pyridylaaol-S-[ N-propyl-N-(3-sulphopropylktminolphenol (5Br-PAPS) and 2\_(5-nitro-2-pyridylazo)-5-[N-propyl-N-(3-sulphopropyl)amino]phenol (nitro-PAPS) in ion-pair reversed-phase liquid chromatography was examin

Comparison of the Binding Constant of De
Comparison of the Binding Constant of Decanesulfonate with β-Cyclodextrin as Determined by Liquid Chromatography with a Water Mobile Phase and Flow Injection Analysis Coupled with Dynamic Surface Tension Detection
✍ Toby E. Young; Keith E. Miller; Robert E. Synovec 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 92 KB

This paper compares two independent methods for the determination of the inclusion complex binding constant between ␤-cyclodextrin (␤-CD) and decanesulfonate. First, reverse-phase liquid chromatography (RP-LC) separations of four surfactants are examined under two conditions for the binding constant