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RET receptor signaling: Dysfunction in thyroid cancer and Hirschsprung's disease

✍ Scribed by Naoya Asai; Mayumi Jijiwa; Atsushi Enomoto; Kumi Kawai; Kengo Maeda; Masatoshi Ichiahara; Yoshiki Murakumo; Masahide Takahashi


Book ID
115175625
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
405 KB
Volume
56
Category
Article
ISSN
1320-5463

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The multiple endocrine neoplasia type 2 (MEN2) syndromes and Hirschsprung's disease (HSCR) are inherited neurocristopathies characterized by medullary thyroid carcinoma (MTC), pheochromocytoma, parathyroid disease, and gastrointestinal neuromatosis. Mutations in the RET proto-oncogene are the underl