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RET gene mutations and polymorphisms in medullary thyroid carcinomas in Indian patients

✍ Scribed by Sharma, B. P. (author);Saranath, D. (author)


Book ID
107584300
Publisher
Indian Academy of Sciences
Year
2011
Tongue
English
Weight
344 KB
Volume
36
Category
Article
ISSN
0250-5991

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Medullary thyroid carcinoma (MTC) occurs sporadically or as part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. In MEN 2A, germline missense mutations are found in one of five cysteine codons within exons 10 and I I in the extracellular domain of the RET protooncogene. I