Guanine nucleotide depletion triggers ce
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Elisa Messina; Paola Gazzaniga; Vanna Micheli; Maria Rosaria Guaglianone; Silvia
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Article
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2003
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John Wiley and Sons
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French
β 211 KB
## Abstract Mycophenolic acid (MPA) specifically inhibits inosineβ5β²βmonophosphate dehydrogenase, the first committed step toward GMP biosynthesis. In its morpholinoethyl ester proβdrug form it is one of the most promising immunosuppressive drugs recently developed. The aim of the present study was