Resveratrol alleviates alcoholic fatty liver in mice
โ Scribed by Ajmo, J. M.; Liang, X.; Rogers, C. Q.; Pennock, B.; You, M.
- Book ID
- 118241406
- Publisher
- The American Physiological Society
- Year
- 2008
- Tongue
- English
- Weight
- 935 KB
- Volume
- 295
- Category
- Article
- ISSN
- 0193-1857
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Gut-derived, endotoxin-mediated hepatocellular damage has been postulated to play a crucial role in the pathogenesis of alcohol-induced liver injury in rodents. Endotoxins induce production of tumor necrosis factor alpha (TNF-alpha) by Kupffer cells via Toll-like receptor (TLR) 4 and contribute to l
Fatty liver, formerly associated predominantly with excessive alcohol intake, is now also recognized as a complication of obesity and an important precursor state to more severe forms of liver pathology including ischemia/reperfusion injury. No standard protocol for treating fatty liver exists at th