Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan
✍ Scribed by Dr. Michael D. Shelby; D. K. Gulati; Raymond R. Tice; J. P. Wojciechowski
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 360 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0893-6692
No coin nor oath required. For personal study only.
✦ Synopsis
Three human carcinogens, 4-aminobiphenyl, All three compounds gave positive results in the treosulphan, and melphalan, were tested for the mouse bone marrow micronucleus test, and melinduction of micronuclei or chromosomal aber-phalan, the only compound tested for aberration rations in the bone marrow cells of male B6C3F1 induction, was positive in this assay. These results mice. These studies were conducted to provide extend the evidence that nearly all known human further information on the in vivo genetic toxicity carcinogens are detected in relatively simple and of compounds known to cause cancer in humans. widely employed short-term in vivo tests.