I n children, regional radiotherapy for localized Hodgkin's disease has produced survival figures comparable to the best reported results in adults. Review of 47 children with Stage I and I1 disease treated at the M. D. Anderson Hospital from 1949 to 1969 demonstrated 80% 5-year survival and 67% 10-year survival. Twenty-seven patients were staged clinically, and 20 were staged following acceptance of lymphography as a staging procedure for children. Celiotomy and splenectomy were not included routinely in the diagnostic studies until 1970. Local control was achieved uniformly. Extensions have been analyzed in relation to initial presentation and specific histology according to the method of Lukes and Butler. Possibilities for improving results with combination treatment programs utilizing radiotherapy and chemotherapy are discussed.
HE OCCURRENCE OF LOCALIZED HODGKIN'S
T disease in children is of sufficient frequency to merit special consideration of the disease characteristics and results of treatment in that segment of the population where growth and maturation are still in progress.1.2 T h e availability of an unusually large number of children with Stages I and I1 Hodgkin's disease, managed by essentially the same team of physicians at the M. D. Anderson Clinics, represents a unique opportunity for study of the clinical course of the disease in children, and for assessment of response to treatment regimens which have evolved over a period of 20 years. Baseline data from such studies are essential for evaluation of more precise methods of staging, as well as more extensive treatment programs.' MATERIAL Forty-seven untreated children' with Stages I and I1 Hodgkin's disease were admitted to the Pediatric Service at the M.