Results and conclusions of the national toxicology program's rodent carcinogenicity studies with sodium fluoride

✍ Scribed by John R. Bucher; Milton R. Hejtmancik; John D. Toft II; Ronald L. Persing; Scot L. Eustis; Joseph K. Haseman

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: French
• Weight: 558 KB
• Volume: 48
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910480517

✦ Synopsis

The U S National Toxicology Program (NTP) has conducted toxicity and carcinogenicity studies with sodium fluoride administered in the drinking water to F344/N rats and B6C3F, mice. The drinking water concentrations used in the 2-year studies were 0, 25, 100, or 175 ppm sodium fluoride (equivalent to 0, I I, 45 or 79 ppm fluoride). Survival and weight gains of rats and mice were not affected by fluoride treatment. Animals receiving sodium fluoride developed effects typical of dental fluorosis, and female rats given I75 ppm had increased osteosclerosis. There were no increases in neoplasms in female rats or in male or female mice that were attributed to sodium fluoride administration. There was equivocal evidence of carcinogenic activity of sodium fluoride in male rats based on the occurrence of a small number of osteosarcomas in treated animals.