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Restriction ofβ-adrenergic responsiveness in hypertrophied ventricular myocardium of rats

✍ Scribed by B. Hein; J. Janke


Publisher
Springer
Year
1977
Tongue
English
Weight
407 KB
Volume
72
Category
Article
ISSN
0300-8428

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Carvedilol, a new beta-blocker with vasodilating properties due to alpha 1-blockade, was investigated in preparations of human ventricular myocardium. Carvedilol demonstrated a high affinity and is a slightly beta 1-selective competitive beta-blocking agent, with a KD for beta 1-receptors of approxi