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Restriction of murine leukemia proviral gene expression in somatic mouse cell hybrids

✍ Scribed by Amos Panet; Haya Falk; Eva Maria Fenyö; George Klein

Book ID
119010120
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
955 KB
Volume
106
Category
Article
ISSN
0042-6822

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Most murine plasma-cell tumors show a t( 12; IS) reciprocal chromosomal translocation which truncates the first exon of one of the myc gene alleles and fuses it to one of the switch regions of the immunoglobulin (Ig) heavy-chain locus. This results in constitutive activation of the translocated myc