Restriction of lipid motion in membranes triggered by β-sheet aggregation of the anti-apoptotic BH4 domain

Synthesis and secondary structure in mem

Synthesis and secondary structure in membranes of the Bcl-2 anti-apoptotic domain BH4

✍ Lucie Khemtémourian; Marc-Antoine Sani; Katell Bathany; Gerhard Gröbner; Erick J 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 294 KB

## Abstract Solid phase synthesis of BH4, the 26 amino‐acid domain (^6^RTGYDNREIVMKYIHYKLSQRGYEWD^31^) of the anti‐apoptotic Bcl‐2 protein has been accomplished using Fmoc chemistry. The use of peculiar cleavage conditions provided high yields after purification such that tens to hundreds of mg cou