Restricted geographical extension of the association of a glucagon receptor gene mutation (Gly40Ser) with non-insulin-dependent diabetes mellitus
โ Scribed by Michael Ristow; Kay Busch; Helmut Schatz; Andreas Pfeiffer
- Book ID
- 116109360
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 217 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0168-8227
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๐ SIMILAR VOLUMES
Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detec
Type 2 (non-insulin-dependent) diabetes is associated with the deposition of islet amyloid. The major formative peptide, islet amyloid polypeptide, has recently been characterised and an abnormality of the structure or expression of this gene is a possible candidate for the inherited component of Ty