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Restricted 12p Amplification and RAS Mutation in Human Germ Cell Tumors of the Adult Testis

โœ Scribed by Helene Roelofs; Marijke C. Mostert; Kirsten Pompe; Gaetano Zafarana; Monique van Oorschot; Ruud J.H.L.M. van Gurp; Ad J.M. Gillis; Hans Stoop; Berna Beverloo; J. Wolter Oosterhuis; Carsten Bokemeyer; Leendert H.J. Looijenga


Book ID
117022300
Publisher
American Society for Investigative Pathology
Year
2000
Tongue
English
Weight
769 KB
Volume
157
Category
Article
ISSN
0002-9440

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Malignant transformation may be caused by gene deregulation resulting from specific chromosomal rearrangements, by amplification, by mutations in proto-oncogenes, by loss of tumor suppressor genes, or a combination of these. We investigated the role of numerical and structural chromosomal abnormalit