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Restraining tumor necrosis factor-alpha by thalidomide prevents the Amyloid beta-induced impairment of recognition memory in mice

✍ Scribed by Tursun Alkam; Atsumi Nitta; Hiroyuki Mizoguchi; Kuniaki Saito; Mitsuru Seshima; Akio Itoh; Kiyofumi Yamada; Toshitaka Nabeshima


Book ID
116284892
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
713 KB
Volume
189
Category
Article
ISSN
0166-4328

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## Abstract Male Wistar rats received unilateral intrahippocampal injections of 3 nmol (3.18 ΞΌg) aggregated AΞ²(25–35), intracerebroventricular bilateral injections of 0.5 ΞΌg human recombinant TNFΞ± or both (AΞ²(25–35) + TNFα‐treated animals). Seven days after the surgery brain sections were stained w