✦ LIBER ✦

Restoring the balance: Harnessing regulatory T cells for therapy in rheumatoid arthritis

✍ Scribed by Fabian Flores-Borja; Claudia Mauri; Michael R. Ehrenstein

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 123 KB
Volume: 38
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.200738107

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Treg play a vital role in the maintenance of tolerance to self antigens, thereby preventing disease through the active suppression of proliferation and pro‐inflammatory cytokine production by autoreactive T cells. Here we discuss strategies aimed at enhancing Treg function in patients with rheumatoid arthritis with the ultimate aim of restoring lasting tolerance but without increasing the risk of infections or cancer.

See accompanying commentary: http://dx.doi.org/10.1002/eji.200838108

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