Restored plasticity in a mouse model of neurofibromatosis type 1 via inhibition of hyperactive ERK and CREB

A mouse embryonic stem cell model of Sch

A mouse embryonic stem cell model of Schwann cell differentiation for studies of the role of neurofibromatosis type 1 in Schwann cell development and tumor formation

✍ Therese M. Roth; Poornapriya Ramamurthy; Fumi Ebisu; Robert P. Lisak; Beverly M. 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 741 KB

## Abstract The neurofibromatosis Type 1 (NF1) gene functions as a tumor suppressor gene. One known function of neurofibromin, the NF1 protein product, is to accelerate the slow intrinsic GTPase activity of Ras to increase the production of inactive rasGDP, with wide‐ranging effects on p21ras pathw