Restored expression of Fhit protein in Fhit-minus breast cancer cells
✍ Scribed by M Campiglio, C Olgiati, P Aiello, CM Croce, S Ménard
- Book ID
- 120700817
- Publisher
- BioMed Central
- Year
- 2001
- Tongue
- English
- Weight
- 293 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr339
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Fragile histidine triad (FHIT) is a tumor suppressor gene whose allelic loss is associated to a number of human cancers. FHIT protein acts as a diadenosine oligophosphate hydrolase, but its tumor suppressive activity appears as independent from its enzymatic activity. Tumor necrosis fac
## Abstract The fragile histidine triad (__FHIT__) gene is a frequent target of deletions in lung cancer. Previous studies have shown that __FHIT__ gene transfer into lung cancer cells lacking FHIT expression results in induction of apoptosis. However, the effect of FHIT expression on apoptosis ind
## Abstract The __FHIT__ tumor suppressor gene, which encompasses the fragile site __FRA3B__ at 3p14.2, is altered frequently in many types of human cancers. To determine its importance as a prognostic marker in breast cancer, the expression of the FHIT protein was studied in a series of 452 breast