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Restoration of Thymocyte Development and Function in zap-70−/− Mice by the Syk Protein Tyrosine Kinase

✍ Scribed by Qian Gong; Lynn White; Robin Johnson; Mike White; Izumi Negishi; Matthew Thomas; Andrew C Chan


Book ID
117722737
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
280 KB
Volume
7
Category
Article
ISSN
1074-7613

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The adapter protein Shc has been implicated in mitogenic signaling via growth factor receptors, antigen receptors and cytokine receptors. Recent studies have suggested that tyrosine phosphorylation of Shc may play a key role in T lymphocyte proliferation via interaction of phosphorylated Shc with do