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Restoration of TGF-β regulation of plasminogen activator inhibitor-1 in Smad3-restituted human choriocarcinoma cells

✍ Scribed by Guoxiong Xu; Chandan Chakraborty; Peeyush K Lala

Book ID
117052078
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
263 KB
Volume
294
Category
Article
ISSN
0006-291X

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## Abstract Transforming growth factor‐β (TGFβ) controls expression of plasminogen activator inhibitor type 1 (PAI‐1), which regulates degradation of extracellular matrix proteins in fibrotic diseases. The TGFβ receptor‐specific Smad 3 has been implicated in the PAI‐1 expression. The mechanism by w